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Fluorescence Widefield Phase Contrast DIC Calcium Imaging

The Nikon Eclipse Ti2-E is an inverted widefield system offering a large field of view, high-quality optics and an industry-leading focus stabilisation system (Nikon Perfect Focus System). he system software includes Nikon JOBS, allowing automation of experimental protocols, including on the go analysis and cell identification. Additionally, a CoolLED pE-340Fura light source enables rapid ratiometric imaging of rapid calcium dynamics.

Fluorescence Confocal DIC

The FV1200 is a filter based upright confocal system. A workhorse of our confocal systems it is well equipped for standard fixed samples where high resolution and sensitivity are required for localization based studies. Additionally as one of the few upright confocal systems within the BMIF it provides a means for visualizing water submerged opaque samples.

Fluorescence Phase Contrast Widefield High Throughput

he IncuCyte S3 is a widefield inverted live cell system engineered with long term high throughput imaging in mind. Housed inside a tissue culture incubator, the imaging module maintains the most stable imaging conditions possible ( 37C temperature, humidity and 5% CO2). The system comes with a selection of versatile inserts allowing you to image your cells in a range of vessels.

Confocal Widefield Airyscan 2 Correlative EM

This LSM 900 is an upright high-end confocal microscope. Equipped with GaAsP detectors and an Airyscan 2 detector it delivers speed and sensitivity without compromising signal to noise. A new multiplex mode for Airyscan 2 gives you the ability to choose between an increase in resolution by 1.7x, improve your signal to noise, or increase you acquisition speed. Additionally, it has a cryo stage facilitating specimen preparation for electron microscopy, allowing correlative microscopy between light microscopy on living specimens, and the high resolution of electron microscopy.

The 3i VIVO microscope is ideally suited for intravital imaging. Its large stable stage can easily accommodate sizable tissue samples along with clamps and manipulators to aid stabilization. Equipped with a spinning disk unit for high speed optical sectioning, paired with an image intensifier, this system can achieve very high frame rates making the most of every photon. Additionally, a pulsed 532nm ablation laser is available for targeted tissue damage. 

Confocal Airyscan Multi-photon FLIM

The Zeiss LSM 880 is an inverted laser scanning confocal microscope equipped with high quantum efficiency GaAsP detector and 2 multialkali PMTs, which can be used as single point detectors or combined for 34 channel spectral imaging. In addition, the Airyscan module can deliver images with 1.7 x improved resolution (140nm axially, 400 nm laterally) and 4-8 x greater signal-to-noise ratio, at the highest speed of any linear scanning confocal system. BiG.2 Type A (2x GaAsP detectors) non-descanned detectors for the multi-photon laser can be used for imaging thick specimens, with deeper penetration and decreased phototoxicity compared to single photon lasers. The Picoquant system utilises the multi-photon laser to perform Fluorescence Lifetime Imaging (FLIM), Fluorescence Correlation Spectroscopy (FCS), Forster Resonance Energy Transfer (FRET). The Zeiss 880 is also equipped with polarisers for anisotropy measurements.