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Slide Scanning Multi-plexing

The Vectra® Polaris™ Automated Quantitative Pathology Imaging System is a new class of tissue imager which provides unparalleled speed, performance, and versatility for visualizing, analyzing, quantifying, and phenotyping immune cells in situ in Formalin Fixed Paraffin Embedded (FFPE) tissue sections and TMAs to advance disease research.

The VisualSonics Vevo3100 uses the new solid-state transducers which offer higher resolution at multiple focal depths. The system offers superior resolution down to 30μm, a wide range of frequencies (13-56 MHz) and a large field of view. Importantly, the Vevo3100 offers a comprehensive imaging and processing packing.

Fluorescence 3D Neuron Tracing

The Zeiss Axio Imager M2 upright microscope with ApoTome 2 with MBF Bioscience software: Stereo Investigator and Neurolucida. This system can be used for neuronal tracing, morphometric quantification, and unbiased stereology (number, length, area and volume of cells and biological structure stereology of histological specimens) in both brightfield and fluorescence. The system is fitted with 6 objectives ranging from 2.5x to 63x, making it ideal for widefield imaging of cells or tissues. The Apotome 2 allows optical sectioning of fluorescent samples by the removal out of focus light with structured illumination (uses grid patterns to calculate the optical sections). The system has both monochrome and colour cameras.  

Fluorescence Widefield Confocal

The Zeiss Celldiscoverer 7 is a boxed imaging system suited for performing automated experiments. This inverted widefield system features automatic focusing, focus stabilisation, time-course and position setup to allow researchers to insert a sample and set up long-term experiments in minutes

The Celldiscoverer 7 has a fully temperature-controlled sample chamber with a CO2 pump, this chamber is highly stable and allows for live cells to stay healthier for longer. By utilising LEDs as a light-source for widefield imaging, live-cells can be imaged gently and with low phototoxicity, making the Celldiscoverer 7 ideal for long-term live experiments. Additionally, an infrared LED is used for transmitted light brightfield and phase contrast imaging through all available objectives and through a variety of sample holders.

Fluorescence Widefeild

The Zeiss Celldiscoverer 7 is a boxed imaging system suited for performing automated experiments. This inverted widefield system features automatic focusing, focus stabilisation, time-course and position setup to allow researchers insert a sample and set up long-term experiments in minutes. The Celldiscoverer 7 has a fully temperature-controlled sample chamber with a CO2 pump, this chamber is highly stable and allows for live cells to stay healthier for longer. By utilising LEDs as a light-source, live-cells can be imaged gently and with low phototoxicity, making the Celldiscoverer 7 ideal for long-term live experiments. Additionally, an infrared LED is used for transmitted light brightfield and phase contrast imaging through all available objectives and through a variety of sample holders.

TIRF Super-resolution SIM Funded by Ramaciotti Foundation

The Zeiss Elyra 7 offers several super-resolution modalities, allowing detailed visualisation of samples beyond the diffraction limit of conventional light microscopy. With 2 fast CMOS cameras, this system allows users to rapidly image multiple colours. The Elyra 7 features Lattice SIM (Structured Illumination Microscopy), allowing fast and gentle super-resolution imaging (~120 nm in xy and ~300 nm in z) in 3 dimensions. The speed of this imaging modality is well suited to capturing dynamic biological processes in live samples. In addition, the Elyra 7 features TIRF imaging for improved signal to noise, and single-molecule localisation imaging for STORM, PALM and PAINT experiments (~20-30 nm xy and ~50-80 nm in z) on fixed samples.

TIRF Super-resolution SIM

The Zeiss Lattice Lightsheet 7 is an easy to use system for performing fast and gentle volumetric imaging of living cells, cellular organelles, and its structures. This inverted fluorescence system features automatic alignment of all optical elements, auto-immersion, time course, positions, and tiles to allow researchers to set up and leave long term experiments.

Lightsheet

Lighsheet microscopy is a fluorescence-based imaging technique that is growing in popularity. It outperforms other techniques in its ability to rapidly capture large optically sectioned three dimensional datasets, whilst keeping photo-toxicity and bleaching to a minimum. It therefore lends itself well to imaging samples larger than those typically attempted by conventional fluorescence microscopy such as tissues, whole organs and even embryo development.

Confocal Spectral Scan

The Zeiss LSM 780 is a high-sensitivity laser scanning confocal microscope. Unlike most standard confocal systems this instrument comes equipped with a GaAsP photodetector. This detector in addition to boasting a quantum efficiency of 45% (in comparison to 25% for standard PMTs), it can also be used as a single-point detector or as a 32-channel detector array facilitating spectral measurements. It can also be switched into a single-photon counting mode providing great signal to noise for such techniques as FCS and RICS.

Confocal Airyscan

The Zeiss LSM 800 is an inverted Zeiss Axio Observer Z1 laser scanning confocal microscope equipped with high quantum efficiency GaAsP detector, 2 multi-alkali PMTs and DIC optics for trans-illumination microscopy with each objective. In addition, the Airyscan module can deliver images with 1.7 x improved resolution (120 nm in x / y and 350 nm in z) and 4-8 x better signal-to-noise ratio, with fast linear scanning. Airyscan works with thicker samples such as fixed tissue sections or whole animal mounts that need a higher penetration depth.

Confocal Airyscan Multi-photon FLIM

The Zeiss LSM 880 is an inverted laser scanning confocal microscope equipped with high quantum efficiency GaAsP detector and 2 multialkali PMTs, which can be used as single point detectors or combined for 34 channel spectral imaging. In addition, the Airyscan module can deliver images with 1.7 x improved resolution (140nm axially, 400 nm laterally) and 4-8 x greater signal-to-noise ratio, at the highest speed of any linear scanning confocal system. BiG.2 Type A (2x GaAsP detectors) non-descanned detectors for the multi-photon laser can be used for imaging thick specimens, with deeper penetration and decreased phototoxicity compared to single photon lasers. The Picoquant system utilises the multi-photon laser to perform Fluorescence Lifetime Imaging (FLIM), Fluorescence Correlation Spectroscopy (FCS), Forster Resonance Energy Transfer (FRET). The Zeiss 880 is also equipped with polarisers for anisotropy measurements.

Confocal Widefield Airyscan 2

This LSM 900 is an inverted high-end confocal microscope. Equipped with GaAsP detectors and an Airyscan 2 detector it delivers speed and sensitivity without compromising signal to noise. A new multiplex mode for Airyscan 2 gives you the ability to choose between an increase in resolution by 1.7x, improve your signal to noise, or increase your acquisition speed. The acquisition software can acquire and stitch tiled images of samples too large to fit within the field of view. It can easily be programmed to capture images of multiple regions on a slide or multi-well plate

Confocal Widefield Airyscan 2 Correlative EM

This LSM 900 is an upright high-end confocal microscope. Equipped with GaAsP detectors and an Airyscan 2 detector it delivers speed and sensitivity without compromising signal to noise. A new multiplex mode for Airyscan 2 gives you the ability to choose between an increase in resolution by 1.7x, improve your signal to noise, or increase you acquisition speed. Additionally, it has a cryo stage facilitating specimen preparation for electron microscopy, allowing correlative microscopy between light microscopy on living specimens, and the high resolution of electron microscopy.